What Are the Different Forms of Ketamine Used for KAP?

When people first hear about ketamine-assisted psychotherapy (KAP), one of the most common questions is: How is ketamine actually given? The truth is, there isn’t just one method. The right form depends on your provider, your body’s needs, and the setting where your treatment takes place.

At United Voices Rising, we want women to feel confident and informed about their options—because understanding the “how” is just as important as the “why” when it comes to your healing journey.

1. Intramuscular (IM) Injection

In this method, ketamine is injected into a muscle (often the upper arm or thigh). The effects begin within a few minutes and last around 45–90 minutes.

• Pros: Quick onset, controlled dosing, and often less expensive than IV infusions.
• Considerations: The dosage can’t be adjusted mid-session, so your provider will work carefully to find the right amount for you.

2. Intravenous (IV) Infusion

IV infusions deliver ketamine directly into the bloodstream through a small catheter in your arm. The dose is usually given over 40–60 minutes.

• Pros: Highly precise dosing and the ability to adjust the infusion during treatment.
• Considerations: Typically requires a specialized clinic setting, which can make it more costly.

3. Sublingual (Under-the-Tongue) Lozenges or Troches

These dissolvable tablets are placed under the tongue or between the cheek and gum. Ketamine is absorbed through the mucous membranes.

• Pros: Can be taken in the comfort of a safe, supervised environment—sometimes even at home under guidance.
• Considerations: Effects can vary depending on how quickly it dissolves and how long you keep it in your mouth.

4. Intranasal (Nasal Spray)

Ketamine nasal sprays are administered through the nostrils. Spravato® (esketamine) is the FDA-approved version for treatment-resistant depression, though other compounded sprays may be used in therapeutic contexts.

• Pros: Less invasive than injections or IVs, and relatively quick onset.
• Considerations: Not all nasal spray formulations are FDA-approved, and availability can vary.

Why the Method Matters

The way ketamine enters your body can affect:

• How quickly you feel the effects
• How long the session lasts
• How intense the experience feels
• The cost and convenience of treatment

Your provider will choose the form based on your health history, comfort level, and therapeutic goals.

The Common Thread: A Safe, Supportive Space

No matter which method is used, KAP is most effective when ketamine is paired with skilled, trauma-informed therapy in a safe, supportive environment. At United Voices Rising, our mission is to ensure women have access to both—the medicine that opens the door, and the compassionate guidance to walk through it.